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α-Synuclein blocks endoplasmic reticulum co-translational protein translocation early in Parkinson’s disease - Nature

Published by Nature.com 6 August 2026 at 12:50
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α-Synuclein blocks endoplasmic reticulum co-translational protein translocation early in Parkinson’s disease - Nature
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What the report says

Proteomic and transcriptomic profiling on hiPSC-derived midbrain dopaminergic neurons with pathological α-synuclein burden reveals defective Sec61A interactions and co-translational translocation of ER-processed proteins.

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