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DCAF11-dependent molecular glue degrader activated by glutathionylation - Nature

Published by Nature.com 5 August 2026 at 18:30
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DCAF11-dependent molecular glue degrader activated by glutathionylation - Nature
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What the report says

M12 is a metabolically activated molecular glue that recruits diverse proteins to DCAF11 for ubiquitin-mediated degradation, revealing a glutathione-dependent mechanism that broadens targeted protein degradation across multiple substrates.

Read the full report at Nature.com →

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